Helene Decaluwe (Alumni) - University of Montreal
|Award Type:||Career Development Award|
Dr. Hélène Decaluwe first completed her medical studies at McGill University (1994-1999) and continued her post-doctoral training in Pediatrics at the University of Montreal (1999-2003). She then pursued her Pediatric Clinical Immunology training in the world-renowned Immunology Unit of Necker-Enfants Malades Hospital in Paris, under the supervision of Alain Fischer (2003-2004). There, she was involved in the diagnosis, treatment and care of children affected by severe immunodeficiency diseases that required hematopoietic stem cell transplantation or gene therapy. In Paris, she also completed a Master’s degree in Immunology (2004-2005) in Jean-Laurent Casanova’s laboratory at the Faculté de Médecine Necker-Enfants Malades where she developed a murine model of complete gamma-interferon receptor deficiency. She then continued her scientific training by a PhD in James Di Santo’s laboratory at the Pasteur Institute (2006-2010). Her thesis project evaluated the role of c-dependent cytokines in the homeostasis and differentiation of T lymphocytes after an acute viral infection, and was supported by grants from the Canadian Institutes of Health Research in association with Bayer and the Canadian Asthma, Allergy and Immunology Foundation, the Fonds de Recherche du Québec - Santé, l’Association pour la Recherche sur le Cancer – France, and Fondation Canadienne Louis Pasteur. In 2010, she was appointed an Assistant Professor position in the Department of Pediatrics of the University of Montreal and has integrated the Allergy, Immunology and Rheumatology division of the CHU Sainte-Justine, where she has been working as a Pediatric Immunologist since. Now an Associate Professor, she established her basic science and translational research laboratory at the CHU Sainte-Justine Research Center, and has been training numerous graduate students while being actively involved on multiple committees in the Research Center as the elected representative of the young investigators. Her laboratory focuses on the role of cytokines in the regulation of T cell differentiation and exhaustion during viral infection and cancer. She is particularly involved in dissecting the mechanisms driving the exhaustion of T and NK cells during chronic viral infection and cancer and on developing new therapeutic approaches to prevent viral or tumor evasion and relapse. She is further involved in basic and translational studies on the immune reconstitution of children treated for severe combined immunodeficiencies by hematopoietic stem cell transplantation. She is supported by grants from the Canadian Institutes of Health Research, the National Institute of Health – USA (Primary Immune Deficiency Treatment Consortium), the Fonds de Recherche du Québec – Santé, the Leukemia and Lymphoma Society of Canada and the Cole Foundation.