Manon Ranger


Pathway: N-STAR


My post-doctoral program builds on my nursing clinical background as a pediatric clinical nurse specialist in acute pain, my nursing graduate studies and Ph.D. training in higher order pain response using functional near-infrared spectroscopy. Thus, my career and academic background in nursing science comprising over 10 years of clinical practice adds a distinctive contribution to my current training in examining the complexity of pain encountered by very preterm infants, and neonatal/pediatric brain development and brain function. I started my postdoctoral fellowship with Dr. Ruth Grunau in September 2012, in Neurosciences at the University of British Columbia Pediatrics’ Department and the Child & Family Research Institute, supported by CIHR and FRQ-S postdoctoral fellowships. My post-doctoral research focuses on examining long-term effects of neonatal procedural pain and additional neonatal factors (e.g. morphine exposure) on brain and neurodevelopment of very preterm children at school age. During my fellowship I have been acquiring knowledge in the complexity of pain in very preterm infants, and neonatal and pediatric neuroanatomy and brain function using neuroimaging techniques such as magnetic resonance imaging and diffusion tensor imaging. During the course of my post-doctoral work, it has become evident to me that blending basic science models and clinical research in an integrated approach greatly improves our understanding of the complexities associated with pain-related stress in the context of preterm birth and extended NICU experience. Preclinical studies allows control of specific potential confounding factors and provide confirmatory evidence for findings in clinical research. Thus, in addition to clinical research, I have been co-leading translational studies on a neonatal mouse model to examine the short and long-term effects of repeated pain and sucrose exposure (i.e. sugar water as a pain reducing strategy) on brain and neurodevelopment outcomes. Together this solid foundation will support my goal to become a clinician scientist conducting translational research with a focus on addressing the impact pain/stress and treatment exposure may have on the developing brain of very preterm infants.

Award type: Postdoctoral

Discipline: Nursing

Centre: University of British Columbia

Supervisors / Mentors: Dr. Cheryl Missiuna

Project Title: Long-term effects of neonatal procedural pain on brain and neurodevelopment of very preterm children at school age

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